Durataf 25mg Tablet
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Description
About Durataf 25mg Tablet
Active Ingredient: Tenofovir Alafenamide (25mg)
Durataf 25mg Tablet is used in the treatment of HIV infection and chronic hepatitis B virus (HBV) infection. This antiviral medication prevents the multiplication of viruses in human cells, stopping them from producing new viruses and helping to clear the infection.
It is essential to follow the prescribed dosage and duration as directed by your healthcare provider. Do not skip doses and complete the entire course of treatment, even if you feel better. Taking this medicine with food increases absorption into the body. Keep using the medication until your doctor advises it is safe to stop.
Common Side Effects
- Headache
- Diarrhea
- Nausea
- Joint Pain
- Abdominal Pain
- Indigestion
These side effects are usually mild and go away over time. If they persist or worsen, consult your doctor. In rare cases, skin reactions or liver damage may occur. Your doctor will monitor you closely during the initial treatment phase.
Important: Before using Durataf 25mg Tablet, inform your doctor if you have any skin problems or liver or kidney disease. Regular blood tests may be required to monitor your blood counts and liver function. Alcohol consumption should be avoided due to the risk of liver damage. Pregnant or breastfeeding women should consult a doctor before use. Practicing safe sex (e.g., using condoms) is advised if you are HIV-positive.
Uses of Durataf Tablet
For the Treatment of Chronic Hepatitis B Virus (HBV) Infection
Durataf 25mg Tablet effectively treats chronic hepatitis B infection, which persists for over six months and is not yet cured. It reduces the chances of complications, such as new infections, and improves the patient’s quality of life. Untreated chronic hepatitis B can lead to severe liver damage, which may cause liver failure or be fatal.
How to Use Durataf Tablet
Take Durataf 25mg Tablet as prescribed, with food, to aid absorption. Swallow the tablet whole; do not chew, crush, or break it.
How Durataf Tablet Works
Durataf 25mg Tablet is an antiviral agent that prevents the replication of viruses in human cells. This stops the virus from producing new viruses and helps to clear the infection from the body.
Safety Advice
Pregnancy
Durataf 25mg Tablet is generally considered safe during pregnancy. Animal studies have shown little or no adverse effects, but human data is limited. Consult your doctor for advice.
Breastfeeding
Durataf 25mg Tablet is likely safe for breastfeeding mothers. Limited human data suggests no significant risk to the baby. Discuss with your doctor for advice.
Liver & Kidney Disease
Kidney Disease: Use with caution in patients with kidney disease. Dose adjustments may be required. Consult your doctor.
Liver Disease: Likely safe for use in liver disease patients. However, consult your doctor to confirm.
Alcohol
It is not clear whether consuming alcohol while taking Durataf 25mg Tablet is safe. Please consult your doctor.
Driving
Durataf 25mg Tablet may cause dizziness or drowsiness. Avoid driving or operating machinery until you know how this medication affects you.
What to Do if You Miss a Dose
If you miss a dose of Durataf 25mg Tablet, take it as soon as possible. However, if it’s nearly time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose.
Quick Tips
- HIV Treatment: Durataf 25mg Tablet is part of a combined treatment plan for HIV infections.
- HBV Treatment: It is used for managing chronic hepatitis B virus infection.
- Take with Food: Always take with food for optimal absorption.
- Avoid Alcohol: Limit alcohol consumption during treatment to reduce liver risk.
- Safety: Do not share needles or personal items like razors or toothbrushes if you are HIV-positive. Use condoms to prevent transmission during sexual activity.
- Regular blood tests will be required during and for at least six months after discontinuation of Durataf 25mg Tablet.
Side Effects of Durataf 25mg Tablet
Serious Side Effects:
Lactic acidosis (symptoms: unusual weakness, muscle pain, cold extremities)
Severe liver problems (symptoms: yellow skin/eyes, tea-colored urine, light stools, loss of appetite)
Severe kidney problems
Common Side Effects:
- Nausea, vomiting
- Diarrhea
- Stomach pain, joint pain
- Rash, itching
- Feeling tired
- Headache, dizziness
Word of Advice
Before starting Durataf 25mg Tablet, be mindful of potential risks, especially during pregnancy, breastfeeding, and if you have pre-existing liver or kidney conditions. Close monitoring is required to ensure the safe use of this medicine, and you should always follow your doctor's advice.
Frequently Asked Questions
Q1: Can Durataf 25mg Tablet be taken with other antiretroviral medications?
Yes, Durataf 25mg Tablet is often combined with other antiretroviral drugs to treat HIV. Your doctor will guide the appropriate combination based on your health status and treatment needs.
Q2: Is Durataf 25mg Tablet safe for older adults?
Durataf 25mg Tablet can be used by older adults, but dosage adjustments or increased monitoring may be necessary due to age-related changes in liver and kidney function.
Q3: Can Durataf 25mg Tablet cause weight gain?
Weight gain is not commonly reported with Durataf 25mg Tablet. However, individual reactions to medications may vary.
Q4: Can it be used during chemotherapy or radiation therapy?
Durataf 25mg Tablet should be evaluated by both an HIV specialist and an oncologist if you are undergoing chemotherapy or radiation to ensure safe use and to avoid drug interactions.
Q5: Should I inform my healthcare provider if I am undergoing surgery or dental procedures?
Yes, inform your doctor or dentist about your medication. They may need to adjust your treatment plan temporarily.
Q6: Can Durataf 25mg Tablet cause lactic acidosis?
Although rare, Durataf 25mg Tablet has been associated with lactic acidosis. Seek immediate medical attention if you experience symptoms like muscle pain, rapid breathing, or abdominal pain.
Fact Box
Molecule Name: Tenofovir Alafenamide
Therapeutic Class: Antiviral Agents
Pharmacological Class: Nucleoside Reverse Transcriptase Inhibitors (NRTIs)
Indications:
HIV-1 Infection
Hepatitis B Infection
References
KD Tripathi, Essentials of Medical Pharmacology, 7th edition, 2013, 808.
Goodman & Gilman’s, The Pharmacological Basis of Therapeutics, 12th edition, 2011, 1615.
Gilead Sciences Ltd, Electronic Medicines Compendium (EMC), Revised Jan 2021, Link
US FDA, Gilead Sciences, Revised Feb 2020